GenTwoArmsTrialSize: Generalized Two Arms Clinical Trial Sample Size Calculation

Two arms clinical trials required sample size is calculated in the comprehensive parametric context. The calculation is based on the type of endpoints(continuous/binary/time-to-event/ordinal), design (parallel/crossover), hypothesis tests (equality/noninferiority/superiority/equivalence), trial arms noncompliance rates and expected loss of follow-up. Methods are described in: Chow SC, Shao J, Wang H, Lokhnygina Y (2017) <doi:10.1201/9781315183084>, Wittes, J (2002) <doi:10.1093/epirev/24.1.39>, Sato, T (2000) <doi:10.1002/1097-0258(20001015);2-0>, Lachin J M, Foulkes, M A (1986) <doi:10.2307/2531201>, Whitehead J(1993) <doi:10.1002/sim.4780122404>, Julious SA (2023) <doi:10.1201/9780429503658>.

Imports: TrialSize, dplyr, Hmisc
Suggests: knitr, rmarkdown
Published: 2023-12-11
Author: Mohsen Soltanifar ORCID iD [aut], Chel Hee Lee ORCID iD [cre, aut]
Maintainer: Chel Hee Lee <chelhee.lee at>
License: GPL-3
NeedsCompilation: no
CRAN checks: GenTwoArmsTrialSize results


Reference manual: GenTwoArmsTrialSize.pdf
Vignettes: tutorial


Package source: GenTwoArmsTrialSize_0.0.4.5.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): GenTwoArmsTrialSize_0.0.4.5.tgz, r-oldrel (arm64): GenTwoArmsTrialSize_0.0.4.5.tgz, r-release (x86_64): GenTwoArmsTrialSize_0.0.4.5.tgz
Old sources: GenTwoArmsTrialSize archive


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