PKPDsim is a library for numerical integration of ODE systems, in particular pharmacokinetic-pharmacodynamic (PK-PD) mixed-effects models.


The development version of PKPDsim always has the most up-to-date improvements and bug fixes. We aim to release PKPDsim on CRAN at least once a year, depending on the number and impact of updates made to the development version.

The CRAN version of PKPDsim can be installed using:


The development version of PKPDsim can be installed using:



We welcome input from the community:


The functionality in this R package is provided “as is”. While its authors adhere to software development best practices, the software may still contain unintended errors.

InsightRX Inc. and the authors of this package can not be held liable for any damages resulting from any use of this software. By the use of this software package, the user waives all warranties, expressed or implied, including any warranties to the accuracy, quality or suitability of InsightRX for any particular purpose, either medical or non-medical.

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