nlmixr2est: Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 2.1.7
Depends: nlmixr2data, R (≥ 4.0)
Imports: backports, checkmate, cli, graphics, knitr, lbfgsb3c, lotri, magrittr, Matrix, methods, minqa, n1qn1 (≥ 6.0.1-10), nlme, Rcpp, rex, rxode2 (≥ 2.0.12), stats, symengine, utils
LinkingTo: BH, lbfgsb3c, Rcpp, RcppArmadillo (≥, rxode2 (≥ 2.0.12), rxode2parse (≥ 2.0.11), rxode2random (≥ 2.0.9)
Suggests: broom.mixed, crayon, data.table, devtools, digest, dplyr (≥ 1.1.0), generics, nloptr, qs, sys, testthat, tibble, withr, xgxr, sfsmisc, rxode2parse (≥ 2.0.11), rxode2random (≥ 2.0.9)
Published: 2023-09-18
Author: Matthew Fidler ORCID iD [aut, cre], Yuan Xiong [aut], Rik Schoemaker ORCID iD [aut], Justin Wilkins ORCID iD [aut], Wenping Wang [aut], Robert Leary [ctb], Mason McComb ORCID iD [ctb], Vipul Mann [aut], Mirjam Trame [ctb], Mahmoud Abdelwahab [ctb], Teun Post [ctb], Richard Hooijmaijers [aut], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Katharine Mullen [cph], Ben Goodrich [ctb]
Maintainer: Matthew Fidler <matt.fidler at>
License: GPL (≥ 3)
NeedsCompilation: yes
Language: en-US
Citation: nlmixr2est citation info
Materials: NEWS
CRAN checks: nlmixr2est results


Reference manual: nlmixr2est.pdf


Package source: nlmixr2est_2.1.7.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): nlmixr2est_2.1.7.tgz, r-oldrel (arm64): nlmixr2est_2.1.7.tgz, r-release (x86_64): nlmixr2est_2.1.7.tgz, r-oldrel (x86_64): nlmixr2est_2.1.7.tgz
Old sources: nlmixr2est archive

Reverse dependencies:

Reverse imports: babelmixr2, nlmixr2, nlmixr2extra, nlmixr2lib, nlmixr2plot, xpose.nlmixr2


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